Where do asbestos fibers accumulate in the cell

As a result of these cellular and molecular events, cleaved asbestos fibers will accumulate in regional lymphonodes, the distal end of the alveolus, and the pleural cavity, particularly at the opening of lymphatic vessels (Figure 1) [1–5].

Which cellular organelle does asbestos affect?

Asbestos increases Δψ_m, which causes the release of cytochrome c from the mitochondria into the cytosol, where caspase-9 and -3 are then activated (2, 4, 29).

How does asbestos get to the pleura?

Pleural plaques are most commonly caused by asbestos exposure. After an individual inhales asbestos, the fibers can embed in the lung lining and cause irritation. Researchers believe the lymphatic system carries the asbestos fibers to the pleura.

Which part of the human body is affected by asbestos fibres?

The asbestos fibers irritate and scar lung tissue, causing the lungs to become stiff. This makes it difficult to breathe. As asbestosis progresses, more and more lung tissue becomes scarred.

Can the body break down asbestos fibers?

Can asbestos be removed from the lungs? No known method exists to remove asbestos fibers from the lungs once they are inhaled. Some types of asbestos are cleared naturally by the lungs or break down in the lungs.