What is etiology of parkinson disease

Parkinson's disease is caused by a loss of nerve cells in the part of the brain called the substantia nigra. Nerve cells in this part of the brain are responsible for producing a chemical called dopamine.

What is the etiology and pathogenesis of Parkinson's disease?

The pathogenesis of both familial and idiopathic PD involves several components; the gross manifestations of the disorder, the underlying neuronal death and cellular pathology, the molecular mechanisms behind progressive degeneration, and the genetic or environmental dysregulation of proteins responsible for cellular ...

What is known about the etiology of Parkinson's disease?

The cause of Parkinson's disease is unknown, but several factors appear to play a role, including: Genes. Researchers have identified specific genetic changes that can cause Parkinson's disease. But these are uncommon except in rare cases with many family members affected by Parkinson's disease.

What is the pathology of Parkinson's disease?

PD is pathologically characterized by the loss of nigrostriatal dopaminergic innervation, although neurodegeneration is not limited to only the nigral dopaminergic neurons but also involves cells located in other regions of the neural network.