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What is included in the treatment plan for a cancer patient with severe hypercalcemia


The mainstay of treatment for cancer-related hypercalcemia is hydration with normal saline and intravenous (IV) bisphosphonates. Hydration alone is not sufficient to achieve and maintain normocalcemia in cancer patients.

What are common management treatments for hypercalcemia?

Initial therapy of severe hypercalcemia includes the simultaneous administration of intravenous (IV) isotonic saline, subcutaneous calcitonin, and a bisphosphonate (typically, IV zoledronic acid [ZA]) (table 1). Isotonic saline – Most patients with severe hypercalcemia have marked intravascular volume depletion.

What is the first line treatment for hypercalcemia?

Aggressive intravenous rehydration is the mainstay of management in severe hypercalcemia, and antiresorptive agents, such as calcitonin and bisphosphonates, frequently can alleviate the clinical manifestations of hypercalcemic disorders.

How do they treat high calcium in cancer patients?

Hemodialysis is the treatment of choice to rapidly decrease serum calcium in patients with heart failure or renal insufficiency. Loop diuretics should be used with caution as even though they may enhance renal excretion, paradoxical hypercalcemia can occur due to bone resorption.




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