What do cytokines do in cancer cells?
Cytokines in cancer development Cytokines are released in response to a diverse range of cellular stresses, including carcinogen-induced injury, infection and inflammation. In these settings, cytokines function to stimulate a host response that is aimed at controlling the cellular stress and minimizing cellular damage.
Why do cancer cells secrete P-glycoproteins?
Cancer cells secrete cytokines to evade drug-induced death. One of the more extensively characterized mechanisms of drug efflux from cancer cells is attributable to dysregulation of the mdr1 gene, which results in abnormally high expression of the protein MDR1, also known as P-glycoprotein (P-gp).
How do pro-inflammatory cytokines contribute to cancer immunotherapy?
Pro-inflammatory cytokines can contribute to cancer immunotherapy, acting on every phase of the cancer immunity cycle. Thus, cytokines can improve antigen priming, increase the number of effector immune cells in the TME and enhance their cytolytic activity.