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  • What is a glycogen debranching enzyme?

    Four residues before an alpha 1-6 bond, corresponding to a branch, glycogen debranching enzyme catalyzes the transfer of three of the four remaining glucose residues to the end of another glycogen chain, where they can again be degraded by glycogen phosphorylase.

  • Why is it important to understand the conformation of glycogen?

    It is essential to understand the conformation of glycogen because glycogenolysis involves the disintegration of this polymer into glucose monomers via distinct enzymes that catalyze the breakdown of glycogen's branches and chains. Glycogen degradation occurs during a fasting state or when there is a low ratio of insulin to glucagon.

  • Is glycogen a branched glucose polymer?

    Glycogen is an extensively branched glucose polymer that animals use as an energy reserve. It is the animal analog to starch. Glycogen does not exist in plant tissue. It is highly concentrated in the liver, although skeletal muscles contain the most glycogen by weight.

  • What is glycogen phosphorylase?

    Corresponding to cytosolic degradation, glycogen phosphorylase, the rate-limiting enzyme of glycogenolysis, cleaves terminal glucose residue connected to a glycogen branch while substituting a phosphoryl group for the alpha 1-4 bond.


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