FST, also known as the fixation index, is an extremely important statistic in population genetics, molecular ecology and evolutionary biology. It is also arguably one of the most famous population genetic statistics you will encounter. FST essentially measures the level of genetic differentiation between two or more populations.
The Fst statistics have been widely applied in population and evolutionary genetics to identify regions of the genome targeted by selection pressures. The FSTest software was developed to estimate and visualize four Fst statistics of Hudson, Weir and Cockerham, Nei, and Wright using high-throughput genotyping or sequencing data.
The FSTest software was developed to estimate and visualize four Fst statistics of Hudson, Weir and Cockerham, Nei, and Wright using high-throughput genotyping or sequencing data. This package provides Z-transformation of results and can estimate FST using a sliding window approach in which the window size is determined by the number of markers.
With this diversity of definition and estimation in mind, we consider estimates of FST published by The 1000 Genomes Project Consortium (2010) of 0.052 for European and East Asian populations and 0.071 for European and West African populations.