The application of the QCM technique in the biopharmaceutical industry can be very useful. As presented above, it was successfully integrated into the analytical panel of particle formation-based root cause investigation, as well as primary packaging, formulation, and drug product process development.
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To sum up, the QCM emerges as an analytical method with a significant potential to become one of the routine analyses in peptide and protein drug product development. However, further studies, especially ones dedicated to precision, accuracy, and robustness of the method are desirable in this field.
QCM devices are simply designed and easy to use analytical instruments. However, they require fundamental knowledge about design and interpretation of generated data. The quartz crystal microbalance provides real-time mass change measurement owing to the application of a quartz resonator.
The work here presented is based on a review paper, ref and references therein, particularly refs [2-3]. It spans extensive research that has been going on for more than a decade and it builds on several studies. Specifically, we will here focus on two studies mentioned in the review – studies where QCM-D was used as one of the tools to explore a l
Measurement data for three representative experiments of vesicles adsorption to Au and subsequent exposure to AH-peptide are shown in Fig. 2. Each of the graphs A, B and C represent a vesicle size category, 'small', 'medium' and 'large'. Figure 2. QCM-D analysis of membrane - peptide interaction and membrane disruption as a function of vesicles siz
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