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Biogenesis of secretory granules

What is the formation process of secretory granules?
Regulated secretory proteins are packaged into nascent secretory granules (which are referred to as immature secretory granules (ISGs)) in a process that is thought to be initiated by selective aggregation of the secretory proteins in the TGN, followed by interaction of the aggregate with the TGN membrane which may
What is maturation of secretory granules?
ISGs undergo maturation while they are transported to and within the F-actin-rich cortex.
This process includes homotypic fusion of ISGs, acidification of their lumen, processing, and aggregation of cargo proteins as well as removal of excess membrane and missorted cargo.
What is in secretory granules?
Secretory granules also called large dense-core vesicles are the important cytoplasmic organelles.
These contain the secretory proteins in the concentrated form and these proteins are released via regulated secretory pathway.
Thus secretory granules serve as storage compartment for the secretory proteins.
Mature secretory granules in endocrine and neural cells consist of a membrane bilayer that surrounds an electron-opaque dense core consisting of condensed secretory materials such as peptide hormones, granin proteins, and processing enzymes.

The biogenesis of secretory granules in endocrine, neuroendocrine, and exocrine cells is thought to involve a selective aggregation of the regulated secretory proteins into a dense-cored structure. The dense-core is then enveloped by membrane in the trans-Golgi network and buds, forming an immature secretory granule.

Biogenesis of secretory granules

What is the formation process of secretory granules?

What is maturation of secretory granules?

What is in secretory granules?