Foods containing vitamin B 12 include meat, clams, liver, fish, poultry, eggs, and dairy products. Many breakfast cereals are fortified with the vitamin. Supplements and medications are available to treat and prevent vitamin B 12 deficiency.
Industrial production of B 12 is achieved through fermentation of selected microorganisms. Streptomyces griseus, a bacterium once thought to be a fungus, was the commercial source of vitamin B 12 for many years.
Bile is the main form of B 12 excretion; most of the B 12 secreted in the bile is recycled via enterohepatic circulation. Excess B 12 beyond the blood's binding capacity is typically excreted in urine.
Mice undergoing in vivo reprogramming were found to become depleted in B 12 and show signs of methionine starvation while supplementing reprogramming mice and cells with B 12 increased reprogramming efficiency, indicating a cell-intrinsic effect.