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Conception in silico de nouveaux inhibiteurs de l'alpha glucosidase

Which compound has high -glucosidase inhibitory activity?
Most of the title compounds exhibited high α-glucosidase inhibitory activity. In this regards, the most potent compound amongst the tested compounds, compound 5 k, with IC 50 =48.66±0.02 μM was 15.6-fold more potent than positive control acarbose.
Is thieno A M anti--glucosidase?
Compound 5 k was a competitive inhibitor and interacted with important residues of the active site of α-glucosidase. In this work, novel anti-α-glucosidase agents, thieno [2,3-b]quinoline-acetamide derivatives 5 a – m have been designed and synthesized. These compounds were evaluated in vitro against yeast α-glucosidase.
How do pharmacophore models predict a-glucosidase inhibitor affinities?
Subsequently, based on analyzing receptor-ligand interactions, pharmacophore models were generated to screen potential a-glucosidase inhibitors from the marketed drug database. The molecular docking studies of hits were performed to predict docking affinities and obtain bioactive conformations of drugs interacting with the protein.
How to find -glucosidase inhibitor from existing drugs?
Pharmacophore-based virtual screening was performed to find α-glucosidase inhibitor from existing drugs. Molecular docking study was carried out to elucidate the binding mode of α-glucosidase and virtual screening hits. Molecular dynamics simulations proved the stability of receptor-ligand interactions in physiological conditions.

Which compound has high -glucosidase inhibitory activity?