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Pathogenesis of ocular tuberculosis: new observations and future

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  • What is the pathophysiology of ocular tuberculosis?

    PATHOPHYSIOLOGY/DEFINITION
    Ocular involvement from TB can either occur as a primary active infection or a secondary infection from a distant site, usually through hematogenous spread.
    The conjunctiva, cornea, and sclera are sites of primary ocular involvement.

  • What are the 4 stages of TB pathogenesis?

    TB infection happens in 4 stages: the initial macrophage response, the growth stage, the immune control stage, and the lung cavitation stage.
    These four stages happen over roughly one month.

  • What are the pathological changes of tuberculosis?

    On microscopic level the tuberculous granuloma is an organized aggregation of immune cells and debris.
    It contains macrophages that have undergone morphological change into epithelioid cells which form into zipper-like arrays around the necrotic centre.
    They retain the ability to phagocytise mycobacteria.

  • The most common ocular TB manifestation is granulomatous uveitis.
    The most common presentation is posterior uveitis.
    The most typical lesions related to ocular TB are choroidal granulomas, occlusive retinal vasculitis, and multifocal serpiginous-like choroiditis.

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Pathogenesis of ocular tuberculosis: new observations and future