N-Acyl derivatives as prodrug forms for amides: Chemical stability and enzymatic hydrolysis of various N-acyl and N-alkoxycarbonyl amide derivatives
Cyclic amide derivatives as potential prodrugs Synthesis and evaluation of N-hydroxymethylphthalimide esters of some non-steroidal anti-inflammatory
Other examples of amide based prodrugs are allopurinol N-acyl derivatives which were found to be more lipophilic than allopurinol itself (74) Carbonates and
work some amide Prodrugs of Diclofenac have been synthesized via acid amine coupling of Diclofenac and ester derivatives of amino acids using HOBT,
Amide prodrugs of NSAIDs: Synthesis and biological evaluation with a hydrolysis study Among various type of prodrugs amide derivatives are
Cyclic amide derivatives as potential prodrugs: N-hydroxymethyl-succinimide-/isatin esters of some NSAIDs as chemical delivery system with improved
by making the corresponding ester prodrug or replacing it with a bioisostere group, which has yl]-3 derivatives of insulin and exenatide (77) that undergo
Amine derivatives as prodrugs Amides not used due to high stability Most common amine derivative used is a Mannich Base prodrug Mannich Base Chemistry
07_18_04_AM.pptx