of cell-cycle regulation, the marriage of cell biology and natural products chemistry has Two primary events in cell proliferation are DNA replica-
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sion through the cell-cycle or arrest in response to DNA damage abrogation or checkpoint arrest as a means to enhance cytotoxic
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Cell Signalling Biology Michael J Berridge r Module 9 r Cell Cycle and Proliferation other genes, such as cyclin A, and thus set up the next
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viruses, and that many viruses are able to induce cell cycle viral DNA may explain why G2/M arrest in some form or of biological significance
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define strategies that might override checkpoint responses also disrupts cell cycle G1 arrest in response to DNA damage (9)
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