The p53 tumor suppressor protein is rapidly induced following treatment of cells with agents which cause DNA double strand breaks (dsbs) leading to cell
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3 déc 2018 · promote the cell cycle checkpoints, DNA repair, cell senescence and intranuclear p53 concentration by means of negative feedback
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7 avr 2006 · other factors; cell cycle control Abbreviations: p53, human p53 gene or protein; UV, ultraviolet light; Chk1/2, checkpoint kinases; MDM2,
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means of eliminating irreparably damaged cells The final outcome of p53 activation depends on growth control and cell cycle checkpoints (e g CIP1/
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these checkpoints To precisely assess the role of p53 in activating cell cycle checkpoints and in cell survival after radiation, we studied the response of
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