Control of Nitrosamine Impurities in Human Drugs
nitrosating reaction between amines (secondary tertiary
An Interpretation of the Reaction of Aliphatic Primary Amines with
In terms of this mechanism diasteriomeric amines should yield the same carbonium ion REACTION OF ALIPHATIC PRIMARY AMINES WITH NITROUS ACID. 869 which is ...
Stereochemistry of the Primary Carbon. VI. The Reaction of Optically
The Reaction of Optically Active. 1 -Aminobutane-1 -d with Nitrous Acid. Mechanism of the Amine-Nitrous Acid. Reaction1. By Andrew Streitwieser Jr.
Migration Ratios Observed in the Reaction of Diarylethylamines with
of aliphatic amines with nitrous acid. Cf. (a) B. R. Alexander “Prin acid via a mechanism similar to that found in other aliphatic amines5—i.e.
Stereochemistry of the Primary Carbon. VI. The Reaction of Optically
The Reaction of Optically Active. 1 -Aminobutane-1 -d with Nitrous Acid. Mechanism of the Amine-Nitrous Acid. Reaction1. By Andrew Streitwieser Jr.
Rearrangements in the Reactions of 2-(4-Substituted
(1) Presented inpart at the Symposium on Reaction Mechanisms at the 75th Reactions of Amines with Nitrous Acid. A. In Water Solu- tion.—The amine ...
Alkylated Derivatives of Ethyl t-Butylmalonate and the
mechanism for amine-nitrous acid reactions. Introduction. Aliphatic amines react with nitrous acid by a presumed mechanism which can be summarized in the ...
Opinion on Nitrosamines and Secondary Amines in Cosmetic Products
Primary amides react with nitrous acid to give the parent acid of the amide and N2 and can be used as nitrous acid traps. Powerful nitrosating agents such as
Reactions of Nitrous Acid
deamination of primary aliphatic amines by nitrous acid1 that the reaction rate has the form. Rate a. [amine] [HNO
Stereochemistry of the Primary Carbon. VI. The Reaction of Optically
Mechanism of the Amine-Nitrous Acid The reaction of re-butylamine with sodium nitrite in acetic acid gives a mixture of esters in which the ratio of re- ...
Migration Ratios Observed in the Reaction of Diarylethylamines with
measurement of 'migration ratios in different types of reactions. The reaction concerned here is that of diarylethylamines (I) with nitrous acid to produce.
Control of Nitrosamine Impurities in Human Drugs
nitrosating reaction between amines (secondary tertiary
An Interpretation of the Reaction of Aliphatic Primary Amines with
primary amines with nitrous acid an alkyldiazo- nium ion has been considered to be an important intermediate.1 The mechanism of the reaction.
Reactions of Nitrous Acid
deamination of primary aliphatic amines by nitrous acid1 that the reaction of ammonia with nitrous acid.3 Schmid ... tion
Reactions of Amines
Reaction as a proton base (Section 19-5 and 19-6). R N. H. H. N. H. H. R. H. X. H-X (proton acid). NaOH amine base ammonium salt. (acidic). • Mechanism:
Kinetics of the Diazotization of Anilines
acid as a standard and the relative rates satisfied a Hammett equation with a p-value of —1.96. The rate of reaction of amines with nitrous acid.
Studies on Amino-hexoses. II. The Mechanism of the Formation of
reaction of nitrous acid upon common amines has been The reaction mechanism has an analogy in the. Curtius' degradation of acid.
The Reaction of Isobutylamine with Nitrous Acid. ?-Complex and the
ir-complex (of Taft's olefin hydration mechanism) as an intermediate in the hydrogen migration aliphatic amines and nitrous acid provides as “free”.
SolomonsSFW Chapter 20
Reactions of Amines with Nitrous Acid Nitrous acid (HONO) is a weak acid and is prepared in situ by reaction of sodium nitrite with a strong aqueous acid Reaction of Primary Aliphatic Amines with Nitrous Acid Primary amines undergo diazotization with nitrous acid The unstable diazonium salts decompose to form carbocations
Nitrosation of volatile Amines at the Workplace
Reaction with HNO2 • Nitrous acid a weak acid is most commonly prepared by treating NaNO2 with aqueous H2SO4 or HCl • In its reactions with amines nitrous acid – participates in proton-transfer reactions – is a source of the nitrosyl cation NO+ a weak electrophile HNO2 H2OH3O + NO 2 + - pK + a = 3 37
THE ACTION OF NITROUS ACID ON ALIPHATIC AMINES - Nature
As part of a study of the mechanism of deamination by nitrous acid aliphatic primary amines• an investigation of the products formed in the reaction of methylamino with nitrous acid
How does pH affect the nitrosation of amines?
- The nitrosation of amines is markedly pH-dependent. The reaction kinetics depends, among other things, on the concentration of unprotonated amine which decreases with decreasing pH. In nitrosation reactions at acid pH, the yield of nitrosamine is determined
How do secondary amines react with nitrosamines?
- Secondary amines react readily in the dark to form nitrosamines; tertiary amines, however, are converted to nitrosamines more rapidly in sunlight. Practically no reaction is observed in a dry atmosphere. The nitrosation appears to take place Table 2.
What is the mechanism of nitrosation reaction?
- 2 Mechanism of the Nitrosation Reaction N-Nitrosamines are formed in the nitrosation reaction from primary, secondary [4] and tertiary [5] amines. The end product of the nitrosation of aromatic primary amines is a diazonium salt; with primary alkyl amines a mixture of products [4] is obtained which
How do amines react under acidic conditions?
- The amine is preferentially attacked in its unprotonated, basic form [7]. Most secondary amines react under acidic conditions according to equation I. I Tertiary amines can be converted to nitrosamines by dealkylative nitrosation.
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