[PDF] sccs retinol

Is there any information for the determination of impurities for retinol?

No information for the determination of impurities was provided for retinol, retinyl acetate or retinyl palmitate.

What do we know about skin absorption studies of retinoids?

Relevant toxicity studies Absorption Skin GI tractus Only limited skin absorption studies for retinoids have been conducted (including ROL and RAL), and the systemic bioavailability is not well understood (Yourick et al., 2008). Although both in vivoand in vitrodata demonstrate that substantial levels

What is the retinol concentration in the liver?

concentration of 20?g retinol/g liver (0.07 ?mol/g) in adults represents a level assumed to maintain adequate plasma retinol concentration, to prevent clinical signs of deficiency and to provide adequate stores.

What is the molecular weight of retinol?

Reference: 40 In plasma, retinol circulates bound to retinol-binding protein (RBP or RBP4; molecular weight - MW -, 24 kDa), the specific vitamin A carrier protein synthetised mainly by the liver, which in turn forms a high MW complex with transthyretin (TTR, 55 kDa).