[PDF] Air Pollution and its Effects on Health – Case Studies India





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(Microsoft PowerPoint - y‚Sz20170212 air pollution

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(Microsoft PowerPoint - y?Sz20170212 air pollution

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Air Pollution and its Effects on Health – Case Studies India

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Air Pollution and its Effects on Health – Case Studies India

Air Pollution and its Effects on

Health - Case Studies, India

Manas Ranjan Ray & Twisha Lahiri

Chittaranjan National Cancer Institute, Kolkata

Air pollution in Indian cities

Critical [PM

10 > 90 g/m 3 Guwahati, Patna, Raipur, Delhi, Faridabad, Dhanbad, Nagpur, Bhopal, Indore, Jalandhar, Ludhiana, Jaipur, Howrah, Kolkata

High [PM

10

61 - 90

g/m 3 Hyderabad, Chandigarh, Ahmedabad, Panjim, Shimla, Bangalore,

Mumbai, Pune, Bhubanshwar

Moderate [PM

10

31 - 60

g/m 3

Kochi, Shillong, Chennai

Low [PM

10 up to 30 g/m 3

Aizwal

CPCB, 2009

Particulate pollutant levels in past

10 years were far above NAAQS

Vehicular emission contributes

to

70% of pollution load

Air Pollution in Kolkata

Objectives

!To prepare a database on the impact of chronic exposure to urban air pollution on the respiratory and systemic health of the residence of Kolkata (former

Calcutta)

!To investigate the underlying mechanism of air pollution-related health impairments at the cellular and subcellular levels for better understanding and management of the problem •!Type of study : Cross sectional with matched controls !Area: Kolkata & Rural West Bengal !Participant :

932 urban male, median age : 44 yr (25 - 58 yr)

!812 rural control, median age : 43 yr (24 - 57 yr) !Urban, occupationally exposed (n = 460):

Traffic policemen - 56

!Road-side hawker - 188 !Auto-rickshaw driver - 82 !Bus driver - 78 !Motor mechanic - 56

Urban, with office job (n = 472)

Study protocol

932 urban male, median age : 44 yr (25 - 58 yr)

812 rural control, median age : 43 yr (24 - 57 yr)

Urban, occupationally exposed (n = 460):

Air pollution

Increases prevalence of upper respiratory symptoms

Air pollution

Increases prevalence of upper respiratory symptoms ...

Seasonal impact on LRS

SES Dry cough Wet cough

High 1 1

Medium 2.31* 1.72*

Low 3.34* 2.20*

Inverse correlation with SES

Epidemiological study on

health hazards of air pollution is in progress

Questionnaire survey for

respiratory symptoms and neurobehavioral problems

Pulmonary function test by spirometry

Parameters measured

FVC, FEV

1 , FEV 1 / FVC, PEFR, FEF

25-75%

0 2 4

0255075100125150175200225250

No. of individuals

FVC (L)

MeasuredPredicted

0 2 4

0255075100125150175200225250

No. of individuals

FEV1 (L/s)

MeasuredPredicted

Lung function of urban group

Air pollution adversely affects lung function

Reduced lung function

Air pollution and COPD

Elastase

PMN

AM (MMP12)

PMN

Fate of airborne pollutants

after inhalation

Alveolar macrophages engulf inhaled PM

Rural Urban

Alveolar Macrophage with engulfed carbonaceous PM

Phagocytosis of ultrafine particles by AM

10 micrometer

Air pollution and pulmonary

inflammation

Adverse cellular lung reaction

Airway infection & inflammation

Air pollution and inflammatory cytokines

1. !Interleukin-6, 2. Interleukin-8, 3. Interleukin-10, 4. Interleukin-12, 5 . TNF-alpha

Iron in AM

Does air pollution affect

the immunity?

CD4+ cells

CD8+ cells

CD19+ cells

CD16+56+

cells CD4+ CD8+

Rural Urban

Immune alterations

CD4 (FL2)

48%
CD8 (FL1) 53%

Rural Urban

Immune alterations ...

1. !CD11b neutrophil, 2. CD11b monocyte, 3. CD18 neutrophil, 4. CD18 monocyte

Immune alterations ...

Does air pollution affect

the cardiovascular system? It is not just the lungs and lower respiratory tract, the cardiovascular system is also affected by air pollution

Dr. Alfred Munzer

Former President, American Lung Association

Air pollution increases heart diseases

Air pollution increases prevalence of hypertension

Giant platelets

Air pollution activates blood platelets

2-fold rise in aggregation & ATP-release

Platelet activation - cardiovascular risk

Neutrophil-platelet aggregates

Monocyte-platelet aggregates

MFI of CD11b/CD18 on leukocytes

increased by 48% !Inflammation and activation of coagulation cascadequotesdbs_dbs2.pdfusesText_2
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