[PDF] Eviplera, INN-Emtricitabine/Rilpivirine/Tenofovir Disoproxil - Chirurgie

Should emtricitabine and rilpivirine be combined?

This should be considered when assessing a patient’s ability to drive or operate machinery. The combination of emtricitabine, rilpivirine and tenofovir disoproxil has been studied as the component products in treatment-naïve patients (Phase III studies C209 and C215).

Are emtricitabine and tenofovir phosphorylated?

Emtricitabine and tenofovir are phosphorylated by cellular enzymes to form emtricitabine triphosphate and tenofovir diphosphate, respectively. In vitro studies have shown that both emtricitabine and tenofovir can be fully phosphorylated when combined together in cells.

Does Eviplera work in HIV patients with rilpivirine?

Eviplera has been studied in two main studies in patients with HIV-1 who had not received HIV treatment before. In the first main study involving 690 patients, Eviplera was compared with a similar combination that had efavirenz in place of rilpivirine.