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NHEJ-Mediated Repair of CRISPR-Cas9-Induced DNA Breaks

19 Sept 2019 NHEJ-mediated gene editing enables highly efficient editing in human long-term HSCs d. NHEJ-mediated editing restores mutant coding frames.

Analysis of NHEJ-Based DNA Repair after CRISPR-Mediated DNA

15 Jun 2021 Keywords: CRISPR; DNA double-strand break; non-homologous end joining; NHEJ-based DNA repair; repair accuracy; genome editing.

AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ

16 Feb 2021 AMPK promotes c-NHEJ in DSB repair d. AMPK phosphorylates 53BP1 at the S1317 site to promote. 53BP1 recruitment.

Cryo-EM of NHEJ supercomplexes provides insights into DNA repair

4 Aug 2021 NHEJ in- volves several proteins including the Ku70/80 heterodimer

Biochemical evidence for Ku?independent backup pathways of NHEJ

New Insights into NHEJ Repair Processes in Prokaryotes

In eukaryotic cells the repair of DNA double strand breaks (DSBs) by the non-homol- ogous end-joining (NHEJ) pathway is critical for genome stability.

H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent

18 Apr 2022 RIF1-dependent NHEJ. Graphical abstract. Highlights d. BOD1L SET1A

ddPCR™ NHEJ Genome Edit Detection Assays

ddPCR NHEJ GED Assays contain a pair of primers a FAM probe

Bacterial NHEJ: a never ending story

31 Jan 2019 Bacterial NHEJ is per- formed by sets of proteins of growing complexity from Bacillus subtilis and Mycobacterium tuberculo- sis to Streptomyces ...

ZEB1 is Required for NHEJ-Mediated DSB Repair in Euchromatin

15 May 2020 to DSBs that promotes NHEJ selectively in euchromatin based on a novel interaction between the EMT-inducing transcriptional repressor ZEB1

[PDF] Nonhomologous DNA End Joining (NHEJ) - CORE

In general two classes of mechanisms exist for repairing double-strand breaks homologous recombination (HR) or nonhomologous end joining (NHEJ) HR requires 

[PDF] Modernizing the Nonhomologous End-Joining Repertoire

11 sept 2013 · Kinase activity is important for NHEJ: Eliminating the catalytic activity of DNA-PK sensitizes cells to DSB-inducing agents and blocks repair of 

[PDF] Genome editing via non- homologous end-joining (NHEJ) and

The NHEJ mechanism acts in most of the cell cycle and is not based on homology to repair DNA causing mutations such as insertions or deletions (indels) or even 

[PDF] Nonhomologous end-joining (NHEJ) Lessons from yeast

NHEJ evolved to repair DSBs when homologous recombination is disadvantageous NHEJ proteins act by re-annealing and joining short overhangs

Nonhomologous end joining: new accessory factors fine tune the

Nonhomologous DNA end joining (NHEJ) is one of the major DNA double-strand break (DSB) repair pathways in eukaryotes The well-known critical proteins

[PDF] Rôle de Ku70/80 dans le recrutement des facteurs du NHEJ portant

recrutement des facteurs du NHEJ portant un motif de fixation à Ku Thèse de doctorat de l'Université Paris-Saclay Préparée à l'Université Paris Sud

(PDF) Non-homologous DNA end joining and alternative pathways

17 mai 2017 · The NHEJ pathway utilizes proteins that recognize resect polymerize and ligate the DNA ends in a flexible manner This flexibility permits 

The Mechanism of Human Nonhomologous DNA End Joining

NHEJ is the major pathway for the repair of DSBs because it can function throughout the cell cycle and because it does not require a homologous chromosome (3 4) 

NHEJ Deficiency and Disease - ScienceDirectcom

View PDF; Download full issue NHEJ Deficiency and Disease Nonhomologous end-joining (NHEJ) is the process by which nonligatable DNA ends become 

Homologous recombination and nonhomologous end-joining repair

The repair of these breaks by both HR and NHEJ pathways is essential for chromosomal stability at these sites [Keywords: Common fragile sites; double-strand