[PDF] antibodies produced by b cells

Each B cell produces a single species of antibody, each with a unique antigen-binding site. When a naïve or memory B cell is activated by antigen (with the aid of a helper T cell), it proliferates and differentiates into an antibody-secreting effector cell.
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  • How do B cells produce IgM?

    Initial naive B cell activation in response to antigen recognition results in IgM antibody secretion. Alternative polyadenylation site selection of the primary transcript results in substitution of a short hydrophilic sequence for a transmembrane domain at the carboxy terminus, resulting in IgM secretion.

  • Are antibodies produced by B cells or plasma cells?

    Plasma cells are differentiated B-lymphocyte white blood cells capable of secreting immunoglobulin or antibodies.

  • Where do B lymphocytes produce antibodies?

    B lymphocytes originate in the bone marrow; their goal is to recognize an antigen. Each of them responds to the antigen in a specific way, as it expresses specific antibodies on the membrane (IgM, CD79a, and CD79b).
  • B cells have B cell receptors (BCRs) on their surface, which they use to bind to a specific protein. Once the B cells bind to this protein, called an antigen, they release antibodies that stick to the antigen and prevent it from harming the body. Then, the B cells secrete cytokines to attract other immune cells.
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