[PDF] b cell receptor types

B cell receptors are made up of four peptides – two light chains and two heavy chains – that comprise two antigen-binding regions. Light chains are classified as either kappa or lambda, while the heavy chains can be IgG, IgA, IgM, IgD, or IgE isotypes.
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  • What type of receptors do B cells have?

    Membrane-bound immunoglobulin on the B-cell surface serves as the cell's receptor for antigen, and is known as the B-cell receptor (BCR). Immunoglobulin of the same antigen specificity is secreted as antibody by terminally differentiated B cells—the plasma cells.

  • How many types of BCR are there?

    Mature B cells express two BCR isotypes, IgM and IgD.

  • Do B cells express IgM and IgD?

    Remarkably, the receptor isotypes IgM and IgD are structurally similar and both are expressed on the surface of mature B cells, in humans as well as in rodents.
  • B cells are a type of lymphocyte that are responsible for the humoral immunity component of the adaptive immune system. These white blood cells produce antibodies, which play a key part in immunity. Each B cell contains a single round nucleus.
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