[PDF] b cells still front and centre in immunology

Despite the maturity of the field of B cell biology, or possibly because of it, discoveries continue to be made that provide fundamental insights into cell biology and into the immune system itself.
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  • Where are B cells located in the immune system?

    B-cells exist in different places depending on their stage of development. In fetuses, the liver makes B-cells. Once you're born, B-cells develop in the spongy tissue inside your bone called bone marrow. They start as hematopoietic stem cells and eventually become B-cells during a process called hematopoiesis.

  • What is the difference between germinal center and B cell follicle?

    Germinal centers form in the center of B cell follicles; during this process, primary follicle cells are pushed to the periphery, where they form a mantle zone around the germinal center. The mantle zone also contains some memory B cells. A secondary follicle is made up of a germinal center and surrounding mantle zone.

  • What are the two locations where both B cells and T cells can be found?

    There are primary and secondary organs involved in the complex development of lymphocytes, but in most cases, B- and T-lymphocytes are generated in bone marrow and in the thymus.
  • The greater part of lymphocyte development in mammals occurs in the specialized environments of the central lymphoid organs—the bone marrow (and the liver in the fetus) for B cells and the thymus for T cells.
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