[PDF] acetylation of alcohol with acetic anhydride mechanism

  • What is the mechanism for the acetylation of an alcohol with acetic anhydride?

    Initially, acetic acid protonates the carbonyl group of acetic anhydride to give a cationic intermediate which is further attacked by the nucleophile to give an alcohol-type intermediate.

  • How is acetylation with acetic anhydride done?

    In a 5 ml round-bottom flask, 1 g of 4a–h was added to an equimolar amount of acetic anhydride containing 1% of VOSO4·5H2O. The reaction was kept under stirring for 2 or 24 h at room temperature. The reaction was then quenched with 50 ml of H2O and kept under stirring for about 15 min.

  • What is the mechanism of action of acetylation reaction?

    Acetylation is a reaction that introduces an acetyl functional group (acetoxy group, CH3CO) into an organic chemical compound—namely the substitution of the acetyl group for a hydrogen atom—while deacetylation is the removal of an acetyl group from an organic chemical compound.
  • Anhydrides react with alcohols to form esters as the main product and a carboxylate as a side product. The reaction is typically run with a base, such as NaOH or pyridine, to remove any acid produced.
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