[PDF] acetate metabolism liver

Free acetate was barely metabolized in the liver because of low affinity, high K(m), of acetyl coenzyme A (acetyl-CoA) synthetase for acetate. Therefore,  Autres questions
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  • Is acetate metabolized by the liver?

    Free acetate was barely metabolized in the liver because of low affinity, high K(m), of acetyl coenzyme A (acetyl-CoA) synthetase for acetate. Therefore, infused ethanol was oxidized only to acetate, which was entirely excreted into the perfusate.

  • What happens to acetate in the liver?

    In summary, the liver barely metabolizes free acetate under normal physiological conditions, but produces acetate in considerably high quantities as a by-product of enhanced ketogenesis.

  • How is acetate metabolized?

    As is the case with all free fatty acids, unbound acetate can't be further metabolized until it is coupled to CoA through a thioester bond. This reaction is catalyzed by ACSS enzymes, which expend ATP to generate the high energy thioester bond between acetate and CoA (Figure 5).
  • We suggest that high concentrations of acetate selectively impair fatty acid metabolism in heart issue. This in turn leads to decreases in ATP production and tissue ATP concentrations that ultimately result in impaired contractile function.
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