[PDF] acetylation of salicylic acid

Acetylation of salicylic acid forms aspirin in acidic medium. Acetic anhydride interacts with salicylic acid in presence of conc. Sulphury acid for production of aspirin and given product of acetic acid. Acetylation of salicylic acid is electrophilic reaction.
View PDF Document


  • How do you Acetylate salicylic acid?

    In this reaction, an excess of acetic anhydride (C4H6O3) is added to a measured mass of salicylic acid (C7H6O3) in the presence of a catalyst, sulfuric acid (H2SO4). The mixture is heated to form the acetylsalicylic acid (C9H8O4) and acetic acid (C2H4O2).

  • Which drug is formed by acetylation of salicylic acid?

    Aspirin, acetylsalicylic acid (3.2. 2), is synthesized by the acetylation of salicylic acid (3.2. 1) using acetic anhydride or acetyl chloride [60–63]. Aspirin exhibits analgesic, fever-reducing, and anti-inflammatory action, and it also reduces aggregation of thrombocytes.

  • What happens when salicylic acid reacts with acetyl chloride?

    Acetyl chloride reacts with salicylic acid in the presence of pyridine to form aspirin. Aspirin is also known as acetylsalicylic acid.
  • Acetylation is a reaction that introduces an acetyl functional group (acetoxy group, CH3CO) into an organic chemical compound—namely the substitution of the acetyl group for a hydrogen atom—while deacetylation is the removal of an acetyl group from an organic chemical compound.
View PDF Document




Experiment 5 - Synthesis of Aspirin

Aspirin is the common name for the compound acetylsalicylic acid widely used as a fever reducer and as a pain killer. Salicylic acid



Reactions of Acetaminophen in Pharmaceutical Dosage Forms: Its

Its Proposed Acetylation by Acetylsalicylic Acid. E. KALATZIS. Abstract 0 Acetylation of acetaminophen (paracetamol) by acetyl- salicylic acid to 0 



??????? 1

Preparation of acetyl salicylic acid: Method I: Preparation of aspirin by using acetyl chloride with salicylic acid. Acetyl chloride is an acyl chloride 



Acetylation of alcohols phenols and salicylic acid by heteropoly

The performance of different forms of heteropoly acids in the presence of acetic anhydride as acetylating agent for acetylation of salicylic acid was compared.



Partial Purification andProperties of the Isoniazid Trans- Acetylation

Acetylation of p-Aminosalicylic Acid *. JOHN W. JENNE t WITH THE TECHNICAL ASSISTANCE OF MARION ORSER. (From the Pulmonary Disease Service 



Acetylation of Prostaglandin Endoperoxide Synthetase with

salicylic acid. It was suggested that the acetylated protein was identical with prostaglandin synthetase since the acetylation and the inhibition of the 



Improving the technology of aspirin manufacture. II. Continuous

catalytic acetylation of salicylic acid with acetic anhydride. Thus the possibility of de- vising a continous scheme for acetylation has appeared.



Reactions of Acetaminophen in Pharmaceutical Dosage Forms: Its

Its Proposed Acetylation by Acetylsalicylic Acid. E. KALATZIS. Abstract 0 Acetylation of acetaminophen (paracetamol) by acetyl- salicylic acid to 0 



Why does aspirin decrease the risk of venous thromboembolism

Sep 5 2014 novel antithrombotic effects of acetyl salicylic acid. J Thromb Haemost 2014; ... to the known acetylation of serine 529 residue in platelet.



Does aspirin acetylate multiple cellular proteins? (Review)

Apr 6 2009 Treatment of cells with salicylic acid alone failed to induce protein acetylation