[PDF] acylation of amines with acetic anhydride

Amines in the form of amine hydrochlorides are efficiently acylated with anhydrides in an aqueous medium on addition of NaHCO 3 . Both cyclic and acyclic anhydrides react with equal ease with an amine and amines of various stereo-electronic factors react with the same rates with an anhydride.
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  • What happens when amine reacts with acetic anhydride?

    Acid Anhydrides React with Amines to Form Amides.22 jan. 2023

  • How is acetylation with acetic anhydride done?

    General procedure. Free nucleoside (1 mmol) was added to 60% acetic anhydride-acetic acid (2 mL). The resulting mixture was heated to 80 oC and kept at this temperature for 4–8 h. Upon completion of the reaction, the solvent was removed under vacuum.

  • Do anhydrides react with amines?

    The reaction of an anhydride and an amine form an amide through nucleophilic acyl substitution. During this reaction three changes in bonding occur. The leaving group is removed from the anhydride. The amine loses a hydrogen.
  • (iii) Acetyl chloride is more reactive and hence more liable to undergo side reaction. Therefore acetic anhydride is preferred for acylation.
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FULL PAPER Chemoselective Acylation of Amines in Aqueous Media

Keywords: Amines / Amides / Acylation / Aqueous media / Chemoselectivity. Amines are efficiently acylated by Acetylation of amines with acetic anhydride.



Mild and eco-friendly chemoselective acylation of amines in

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