[PDF] amide hydrolysis under acidic conditions

What is acid catalysed amide hydrolysis? It is a reaction of the amide with water in an acidic medium. In an acidic medium, amide interacts with the water molecule to give a carboxylic acid and the salt of ammonia or amine salt.
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  • What are the conditions for hydrolysis of amides?

    Typical conditions for hydrolysis of an amide involve heating the amide with aqueous acid for extended periods.
    Cyclic amides are called, “lactams”.
    Just as undoing a belt results in a simple strip of leather, hydrolysis of a cyclic lactam results in a linear amino acid.7 oct. 2019

  • What are the products of acidic hydrolysis of an amide?

    The hydrolysis of an amide produces a carboxylic acid and ammonia or an amine.

  • Can amides react with acids?

    Amides can be hydrolyzed into a carboxylic acid and ammonia or an amine by heating in an acidic or basic aqueous solution.
    In both cases, acid-base reactions occurring with the products make the overall reaction irreversible.

  • Can amides react with acids?

    Amides generally are formed from acid chlorides, acid azides, acid anhydrides, and esters.
    It is not practical to prepare them directly from an amine and a carboxylic acid without strong heating or unless the reaction is coupled to a second reaction that "activates" the acid.

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Mild hydrolysis or alcoholysis of amides. Ti(IV) catalyzed conversion

Reaction of primary amides (e.g. l a or 6-13) or 0-methylhydroxamates (lb and lc) Les conditions d'hydrolyse dCcrites ne compromettent pas I'intCgritC.



A mild alkaline hydrolysis of N- and NN-substituted amides and

In general nitriles and amides are exceptionally stable to acid and basic hydrolysis and classically they are hydrolyzed under vigorous reaction conditions 



The Hydrolysis of Vitamin B12. Studies with Model Amides

these and other model amides in aqueous hydrochloric acid-dioxane at 50° are recorded. Aquocobalamin has been hydrolyzed under identical conditions; 



Theoretical Studies of Hydrolysis and Stability of Polyacrylamide

The hydrolysis reaction of the amide group (AM) to form acrylic acid (AA) is amide hydrolysis under different conditions have been extensively studied ...



Principles of Drug Action 1 Spring 2005

http://webhome.auburn.edu/~deruija/pda1_amides.pdf



Catalysis of Amide Hydrolysis and Formation under Neutral

by H20 and aniline or morpholine under conditions comparable to those used for the catalyzed hydrolysis of the amides. Experimental Section. General.



Study on Hydrolysis Properties and Mechanism of Poly(3

10. jul. 2022 product under acidic conditions [8] and the carboxylate was preferred under ... when the amide was hydrolyzed under alkaline conditions.



Study on Hydrolysis Properties and Mechanism of Poly(3

10. jul. 2022 product under acidic conditions [8] and the carboxylate was preferred under ... when the amide was hydrolyzed under alkaline conditions.



THE KINETICS OF HYDROLYSIS OF THE AMIDE GROUP IN

mechanism by which free aspartic acid is liberated from proteins under mild conditions of acid hydrolysis.8-11. Earlier workers have provided fragmentary 



Models of zinc-containing proteases. Catalysis of cobalt(III

Abstract: The rate of intramolecular amide hydrolysis in substitutionally inert Co(III) corresponding trans isomer under acidic conditions (D). The.