[PDF] best practice in therapeutic drug monitoring

  • What are the major considerations in therapeutic drug monitoring?

    BASIC PRINCIPLES OF THERAPEUTIC DRUG MONITORING • The following are important considerations to ensure an optimum TDM service in any setting: (1) Measurement of patient's serum or plasma drug concentration taken at appropriate time after drug administration (2) Knowledge of pharmacological and pharmacokinetic profiles

  • Which technique is used for therapeutic drug monitoring?

    Commonly Used Testing Strategy
    Quantitative testing for TDM may be performed by immunoassay, high performance liquid chromatography (HPLC), or mass spectrometry.
    Drug results that are reported as less than the assay cutoff should be interpreted as “not detected.”

  • What is the single most important factor in therapeutic drug monitoring?

    Accurate timing of sample collection is often an important factor in TDM, especially when timed samples such as peak or pre-dose (trough) samples are the primary means of monitoring.

  • What is the single most important factor in therapeutic drug monitoring?

    The indications for TDM are suspected dose-related toxicity, suspected noncompliance, acute overdose, chronic abuse, reduced kidney or liver function, potential interaction with other drugs, evaluation of absorption, and optimalization of treatment.

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