[PDF] hydrolysis of paracetamol

What is the hydrolysis of paracetamol (acetaminophen) in acidic solution?

• Hydrolysis of Paracetamol (acetaminophen) in acidic solution produces an amine (4-aminophenol) and a carboxylic acid (acetic acid) H2O/H2SO4 O H ? || | + HO – C – C - H | H Paracetamol Ethanoic acid 4-aminophenol (acetaminophen) (acetic acid) f

How does paracetamol dissolve in water?

This high solubility level allows paracetamol to dissolve readily in room temperature water along with the desired codeine in the pills. With refrigeration and subsequent lowering of the water temperature to the near freezing temperature of ~0°C, the paracetamol waste product is then removed by filtration.

What is the effect of NaOH on hydrolysis of paracetamol?

So, NaOH was selected for the hydrolysis of paracetamol in subsequent experiments. The effect of NaOH concentrations was also examined in the range 1.0–6.0 mol l ?1. The result showed that the hydrolysis yield increased with increasing NaOH concentrations. However, above the concentration of 4 mol l ?1, hydrolysis yield declined.

How to prepare a stock solution of paracetamol?

A stock solution of paracetamol (The Institute of Pharmaceutical and Bio-material Authentication, China) 4.3×10 ?3 mol l ?1 was prepared by dissolving 325 mg of the solid product in 500 ml distilled water using an ultrasonic water bath to ensure a complete dissolution. This solution was kept in a dark bottle, and was highly stable for long time.