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L'allèle muté responsable de la maladie est dominant sur l'allèle 'sauvage': la maladie s'exprime chez les all in the BMP/TGF-beta family Nat Rev Genet 4: 

[PDF] A comparison of dominance mechanisms and simple mutation on

alter their dominance characteristics Dominance change is achieved in the Ng- Wong diploid by inverting the dom- inance values of all allele-pairs, such that 11  

Genetic identification of dominant overproducing mutations: The

a dominant mutation is readily reverted by gene dele- tion and if gene deletions tations will include, of course, all dominant mutations that produce the right 

Review article The molecular basis of genetic dominance

For simplicity I will use the term 'dominant mutation' to and amino acid substitutions may all be re- sponsible silent, concurrent mutations at both loci cause

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