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Develop from stem cells in the bone marrow and differentiate into antibody- producing plasma cells in the blood – Are capable of making a vast number
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Antigen-Independent B-Cell Development 1 DNA rearrangements establish the primary repertoire, creating diversity 2 Allelic exclusion ensures that each
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selection of B 1 B cells producing the natural antibodies [28] Differentiation into this B sublineage thus seems to be instructed by BCR signals However, all
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ment, in which antigen is the main regulator of effector function The B-cell response and development of humoral memory to thymus (T)-dependent antigens
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B cell generation, Activation, and A COMPARISON OF T CELL AND B CELL MATURATION T cells B cells Activation of B cells by T-dependent antigens
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➢ Isotype switching is the phenomenon mostly restricted to T cell dependent antigen Humoral immune response is governed by the antibodies that are secreted
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13 nov 2014 · B cell activation • Two major types: T cell dependent (TD) and T cell independent (TI) • TD: involves protein antigens and CD4+ helper T cells
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of B cells, proliferation at various stages, and movement within the bone marrow microenvironment Antigen-Independent (Maturation) 1) Pro-B stages
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