Monoclonal antibodies (MW 150 kDa) are composed of one heavy chain (MW 50 kDa) and two types of light chains (kappa and lambda, MW 25 kDa) 2 They generally exhibit charge heterogeneity from oxidation, asparagine deamidation, aspartic isomerization, lysine truncation, glycan modifications, and other modifications
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Mechanisms of Heterogeneous Distribution of Monoclonal
There is a preferential distribu tion of antibodies in areas closest to blood vessels, and there are many regions with zero or negligible antibody (1, 2) This is
[PDF] Antigens & Antibodies II Polyclonal antibodies vs Monoclonal
Monoclonal antibodies do not form lattices with homogeneous, monomeric proteins, because only they can bind to only one epitope on the antigen
Monoclonal antibody MA454 reveals a heterogeneous - Nature
We previously developed MA454, a monoclonal antibody (mAb) to MAGE-1 recombinant protein By employing antigen retrieval techniques, we show that
Calculation of Antibody Affinity in Homogeneous and
The dilutions, the original fractions bound, and the fitted values calculated for each dilution of this bimodal experi- ment are contained in Table 3 The final binding
ANTIGENIC HETEROGENEITY OF BREAST CELL LINES
Three monoclonal antibodies raised in this laboratory to human breast epithelial cells (Table 1) reveal antigenic heterogeneity in normal human breast (Edwards
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