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draw the mechanism of ester hydrolysis under acidic and basic reaction understand why protonation of an amide occurs on oxygen and not on nitrogen;



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evident that amide hydrolysis, being a relatively simple reaction, Amide Hydrolysis i,n Viva defined over a limited range in the case of ester hydrolysis by



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ysis of specific substrates, ester or amide derivatives of aromatic amino acids In these reactions, only transient enzyme-sub- strate complexes are known to 

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