Partnership Among Federal State
Tribal and Territorial Law
CONSTITUTION OF OCTOBER 4 1958
OF OCTOBER 4. 1958 2008-103 of February 4
MS_2010_04_411.pdf (136.7Ko)
En 1989 le gène POU5f1 codant pour le facteur de transcription OCT4 (ou OCT3/4) a été identifié chez la souris
Oct-4 module la spécification puis la différenciation des cellules
Ces résultats suggèrent ainsi qu'Oct-4 régule l'expression de ses gènes cibles de manière dose-dépendante. Introduction. Les cellules souches embryonnaires
PUBLIC LAW 97-280—OCT. 4 1982 96 STAT. 1211 Public Law 97
97th Congress. Joint Resolution. Authorizing and requesting the President to proclaim 1983 as the "Year of the Bible". Oct. 4 1982. [S.J. Res. 165].
Michigan State Waterways Commission Oct. 4 2019 minutes
4 oct. 2019 Chair Dennis Nickels called the meeting to order at 10:51 a.m.
U.S. Department of the Treasury How Emergency Rental Assistance
4 oct. 2021 October 4 2021. This document explains the structure of the Treasury Department's approach to reallocating funds under the first Emergency ...
KOA 24 OCT 4 NOV
24 oct. 2021 24 octobre > 4 novembre. OUVERTURE DES INSCRIPTIONS LE 4 OCTOBRE. Modalités et programme sur valenceromansagglo.fr. 04 75 72 84 53.
Cinéma 28 sep – 4 oct 2022 TAP Castille
il y a 3 jours Chaque mardi retrouvez le programme cinéma en vous inscrivant à la newsletter sur tap-poitiers.com. 28 sep > 4 oct mer 28 jeu 29 ven 30 sam 1.
What is the function of Oct-4?
Oct-4 is a homeodomain transcription factor of the POU family. It is critically involved in the self-renewal of undifferentiated embryonic stem cells. As such, it is frequently used as a marker for undifferentiated cells. Oct-4 expression must be closely regulated; too much or too little will cause differentiation of the cells.
What happens if you don't have Oct-4?
Oct-4 can form a heterodimer with Sox2, so that these two proteins bind DNA together. Mouse embryos that are Oct-4 deficient or have low expression levels of Oct-4 fail to form the inner cell mass, lose pluripotency, and differentiate into trophectoderm.
Is Oct4 a POU transcription factor?
Moreover, while Sox2, Klf4, and cMyc could be replaced by their respective family members, Oct4's closer relatives, Oct1 and Oct6, fail to induce pluripotency, thus demonstrating the exclusiveness of Oct4 among POU transcription factors.
How does Oct-4 affect ectodermal differentiation?
Changes to Oct-4 levels do not independently promote differentiation, but are also controlled by levels of Sox2. A decrease in Sox2 accompanies increased levels of Oct-4 to promote a mesendodermal fate, with Oct-4 actively inhibiting ectodermal differentiation.
