24 oct. 2013 Anhydro-Daptomycin ß-aspartyl Isomer and Lactone. Hydrolysis product of Daptomycin. Changes are made to the purification steps and to the ...
CUBICIN® (daptomycin for injection) for Intravenous Use. Initial U.S. Approval: 2003 If an allergic reaction to CUBICIN occurs
diverse natural products with extraordinary pharmacological importance.1 The bioactivity of amino acids in the daptomycin lactone ring are found at the.
26 janv. 2017 Assessment report. EMA/109959/2017. Page 2/20. Administrative information. Name of the medicinal product: Daptomycin Hospira. Applicant:.
degradation products namely anhydro-daptomycin ß-aspartyl isomer and lactone hydrolysis product of daptomycin. The only solvent used during synthesis is a
A key determinant of nonribosomal peptide product activity is the common yielding solely the decapeptide lactone ring along with decreased hydrolysis.
12 nov. 2015 a generic version of Cubist's daptomycin product which led Cubist to file this action charging Hospira with patent infringement.
12 nov. 2015 a generic version of Cubist's daptomycin product which led Cubist to file this action charging Hospira with patent infringement.