Metabolism of the amide local anesthetics is extensive in all species and is the primary factor limiting the length and intensity of anesthesia and
Since amide-type local anesthetics are metabolized by the liver prilocaine should be used with caution in patients with hepatic disease.
blood flow implying that drug metabolism with the liver has been affected.5 esis that propranolol inhibits amide local anesthetic me-.
Local anesthetics are classified chemically as amides and esters. Ester anesthetics are metabolized more quickly and are consid-.
Metabolism. Astra. Pain. Control. AB. (Received. January. 1 5
The anti-inflammatory effects of the amide local anaesthetics lidocaine and bupivacaine were evaluated in vitro by examination of the metabolic activation
Because amide-type local anesthetics such as ropivacaine are metabolized by the liver these drugs
2 juil. 2021 amide anesthetics (Figure 1). ... and amide anesthetics). ... vacaine and ropivacaine undergo primarily liver metabolism to.
The rate of metabolism among amides varies. prilocaine> lidocaine> mepivacaine> ropivacaine> bupivacaine. Prilocaine metabolites include o-toluidine derivatives
18 déc. 2019 amide which are responsible for the anesthetic classifica- tion (Table 1).5