1 jan. 1980 Androgen binding protein. ABP is a protein found in the testicular cytosol or secreted by Sertoli cells in the rete testis fluid. It has ...
Mots Clds : Androgen-binding protein transgd- n~se
KARN 1984) codes for the Alpha subunit of ABP and rename the locus Androgen binding protein alpha (Abpa). A study of recombinant inbred strains
An androgen binding protein (ABP) has been demonstrated in testis and epididymis (caput corpus
androgen - FSH. Androgen binding protein (ABP) is synthesized in Sertoli cells (Hansson et al. 1975) under the influence of both androgens
Androgen-binding protein (ABP)/sex hormone-binding glob- ulin gene expression has been described in the rat testicular. Sertoli cell and brain.
La demi-vie de la SBP est de 7 jours. Synonymes : SBP = Sex Steroid Binding Protein = Sex. Hormone Binding Globulin = SHBG = TeBG = Testosterone-estradiol
of androgen-binding protein (ABP) to the completion of spermiogenesis was examined in mature rats given daily injections of 25 or 250 g=mgkgm=-body
binding domain on human sex hormone binding globulin. (En- docrinology 129: 690-696 1991). ANDROGEN-BINDING protein (ABP)
184. 54505 Vandoeuvre - les- Nancy
Androgen binding protein, ABP, was initially characterized as a Sertoli cell product in rodents and other small mammals. In these species it is thought to function to concentrate androgens in the seminiferous tubules and deliver the steroid hormone to developing spermatocytes and spermatids.
Androgen-binding protein (ABP) is synthesized by the Sertoli cell in the testis, where ~80% is secreted into the luminal fluid and the other ~20% is secreted into the interstitial compartment and taken up into the systemic circulation.
Rich and de Kretser (1977) damaged rat seminiferous epithelium by several methods and found a relationship between elevated serum FSH and a reduced ability of the Sertoli cells to secrete androgen-binding protein.
Action Androgen action involves pre-receptor, receptor and post-receptor mechanisms that are centered on the binding of testosterone (or an analog) to the androgen receptor. Testosterone undergoes pre-receptor activation by conversion to potent bioactive metabolites, DHT and estradiol.