Theoretical Study of Base-Catalyzed Amide Hydrolysis: Gas-and
Even though acids can promote amide hydrolysis base catalysis is generally more efficient.1 In a number of studies on aliphatic amides
Carboxylic acid participation in amide hydrolysis. External general
Carboxylic Acid Participation in Amide Hydrolysis. External General Base Catalysis and General Acid. Catalysis in Reactions of Norbornenylanilic Acids.
Amide Hydrolysis. Superimposed General Base Catalysis in the
and Mr. E. A. Peterson for his expert programming. Amide. Hydrolysis. Superimposed. General Base Catalysis in the Cleavage of Anilides1.
On the hydrolysis mechanisms of amides and peptides
20 ???. 2018 ?. amide formamide
Stereoelectronic control in acid and base catalysis of amide
model species for acid-and base-catalyzed decomposition of the tetrahedral intermediate in amide hydrolysis have been com- puted: nitrogen protonation leads
Base-promoted hydrolysis of amides at ambient temperatures
sis with base. However base hydrolysis of amides is fre- quently an inefficient process. While addition of hydroxide ion to an amide of general formula 1
Theoretical Studies of Hydrolysis and Stability of Polyacrylamide
The hydrolysis reaction of the amide group (AM) to form acrylic acid (AA) is significantly affected by the pH C for the base-catalyzed amide hydrolysis.
General base catalysis in acidic solutions. Acceleration of
RONALD KLUGER and C.-H. LAM. Can. J. Chem. 55640 (1977). The hydrolysis of the amide linkage of 2'-phosphonobenzanilide
Catalytic Efficiencies in Amide Hydrolysis. The Two-Step
base-catalyzed amide hydrolysis is consistent with either of two mechanisms: (I) the reversible addition of hydroxide ion to the carbonyl function followed
A mild alkaline hydrolysis of N- and NN-substituted amides and
Moreover the hydroxides instead of attack the carbonyl can act as a base and abstract a proton from the primary or secondary amide
