The Download link is Generated: Download https://www.ema.europa.eu/documents/scientific-discussion/cubicin-epar-scientific-discussion_en.pdf


A Review on Daptomycin; the first US-FDA approved Lipopeptide

24 oct. 2013 Anhydro-Daptomycin ß-aspartyl Isomer and Lactone. Hydrolysis product of Daptomycin. Changes are made to the purification steps and to the ...



?30 mL/min

CUBICIN® (daptomycin for injection) for Intravenous Use. Initial U.S. Approval: 2003 If an allergic reaction to CUBICIN occurs



Synthesis and Derivatization of Daptomycin: A Chemoenzymatic

diverse natural products with extraordinary pharmacological importance.1 The bioactivity of amino acids in the daptomycin lactone ring are found at the.



Daptomycin Hospira INN-daptomycin

26 janv. 2017 Assessment report. EMA/109959/2017. Page 2/20. Administrative information. Name of the medicinal product: Daptomycin Hospira. Applicant:.



Cubicin NNI-Daptomicyn

degradation products namely anhydro-daptomycin ß-aspartyl isomer and lactone hydrolysis product of daptomycin. The only solvent used during synthesis is a 



Chemoenzymatic and Template-Directed Synthesis of Bioactive

A key determinant of nonribosomal peptide product activity is the common yielding solely the decapeptide lactone ring along with decreased hydrolysis.



United States Court of Appeals for the Federal Circuit

12 nov. 2015 a generic version of Cubist's daptomycin product which led Cubist to file this action charging Hospira with patent infringement.



United States Court of Appeals for the Federal Circuit

12 nov. 2015 a generic version of Cubist's daptomycin product which led Cubist to file this action charging Hospira with patent infringement.