https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-development-production-characterisation-and-specification-monoclonal-antibodies-and-related-products-revision-1_en.pdf
30 мая 2012 г. • Fc-associated functions (e.g. antibody-dependent cell-mediated cytotoxicity ADCC; ... Although each of the factors mentioned here do not ...
20 нояб. 2018 г. As demonstrated here this approach can be used to design biologically active antibodies
In some instances antibodies can modify the function of the antigen molecules toward which they are directed without being necessarily connected to the
5 окт. 2023 г. It has been widely assumed that these nonneutra- lizing antibodies do not function in a protective way in vivo and therefore are not desirable.
18 дек. 2020 г. These antibodies can bind and hydrolase pathogen-specific target molecules thus potentially contributing to the immune defence. Indeed
Influenza vaccination can also boost Fc-functional antibodies targeting divergent strains of influenza virus. Healthy adults immunized with a quadrivalent
since prior episodes of H influenzae do not confer immunity. By age 5 years most children have naturally acquired antibodies. The HIB conjugate vaccine
18 мая 2023 г. entists can make and use every functional antibody if they simply fol- low the “roadmap” or “conservative substitution.” These two ap ...
15 апр. 2023 г. In addition to neutralization antibodies can ... Specifically
20 août 2020 modifications that can influence not only effector functions but also distribution and persistence of the antibody in different tissue ...
is conjugated to an antibody that targets a specific anti- gen2–5. Molecular techniques that can alter antibody pharmacokinetics effector function
https://www.mdpi.com/2073-4468/8/2/28/pdf
21 avr. 2021 Broad genus patent claims that cover the antibodies and variants of the antibodies
12 févr. 2021 Fc effector functions of antibodies can promote immune-mediated cellular clearance enhance antigen presen- tation and CD8+ T cell responses ...
mAbs can diminish viral dissemination by direct action involving both their antigen-binding activity and the effector functions borne by their Fc fragment.
22 sept. 2021 Antibody functionality. (neutralizing / epitopes / affinity). Antibody location. Number and specificity T cells. T cell ratios.
HOW IS HASHIMOTO THYROIDITIS TREATED? Patients with elevated TPO antibodies but normal thyroid function tests (TSH and Free T4) do not require treatment.
basic function of the human immune system. The following These antibodies can protect the ... monoclonal antibody products do not because they are.
These highlights of the EUA do not include all the information to extend antibody half-life (YTE) reduce antibody effector function