Biopharmaceutics and pharmacokinetics unit 1 pdf

Pharmacokinetics is currently defined as the study of the time course of drug absorption, distribution, metabo- lism, and excretion.
Clinical pharmacokinetics is the application of pharmacokinetic principles to the safe and effective therapeutic management of drugs in an individual patient.
This is closely related to but distinctly different from pharmacodynamics, which examines the drug's effect on the body more closely.
This field generally examines these four main parameters: absorption, distribution, metabolism, and excretion (ADME).

What are pharmacokinetic problems?

Irreversible removal of drug from the body Pharmacokinetics problems:

Poor bioavailability

short duration

high first pass metabolism

side effects and nospecificity Linear pharmacokinetics :

zero order kinetics

rate of elimination of drug remain constant irrespective of drug concentration.
The constant of drug is eliminated per unit time.

What is the difference between Pharmaceutics and pharmacokinetics?

Glossary Pharmaceutics:

S tudy of fabrication of dosageform.
Biopharmaceutics:Study of relationship between drug and drug product and its bioavailability clinical effect and adverse effect.
Pharmacokinetics:.
The study of rate of Absorption, distribution, metabolism and excretion of drug. (What the body does to the drug.

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