Biopharmaceutics and pharmacokinetics distribution slideshare

How does drug distribution occur?

After a drug enters the systemic circulation, it is distributed to the body's tissues.
Distribution is generally uneven because of differences in blood perfusion, tissue binding (eg, because of lipid content), regional pH, and permeability of cell membranes..

What are the factors affecting distribution in pharmacokinetics?

Factors affecting distribution of drug

What are the factors affecting distribution in pharmacokinetics?

Several factors impact drug distribution.
These factors include the concentration of drug transporters in blood, pH, perfusion, body water composition, body fat composition, and most certainly disease conditions (e.g., volume depletion, burns, third spacing)..

What is distribution of drugs in pharmacokinetics?

Drug distribution is the disbursement of an unmetabolized drug as it moves through the body's blood and tissues.
The efficacy or toxicity of a drug depends on the distribution in specific tissues and in part explains the lack of correlation between plasma levels and the effects that are seen..

What is meant by distribution in biopharmaceutics and pharmacokinetics?

Distribution in pharmacology is a branch of pharmacokinetics which describes the reversible transfer of a drug from one location to another within the body.
Once a drug enters into systemic circulation by absorption or direct administration, it must be distributed into interstitial and intracellular fluids..

What is pharmacokinetics distribution process?

Distribution is the process by which drug passes from the bloodstream to body tissues and organs.
It is how a drug moves from intravascular space, e.g. blood vessels, to extravascular space, e.g. body tissues, as it is carried around the body by the circulatory system (figure 1)..

What is the distribution phase of pharmacokinetics?

Distribution: Describes the journey of the drug through the bloodstream to various tissues of the body.
Metabolism: Describes the process that breaks down the drug.
Excretion: Describes the removal of the drug from the body..

What is the importance of distribution in pharmacokinetics?

Drug distribution is the disbursement of an unmetabolized drug as it moves through the body's blood and tissues.
The efficacy or toxicity of a drug depends on the distribution in specific tissues and in part explains the lack of correlation between plasma levels and the effects that are seen..

What is the pharmacokinetic distribution?

Distribution.
Distribution is the process by which drug passes from the bloodstream to body tissues and organs..

What is the pharmacokinetic process of distribution?

Distribution is the process by which drug passes from the bloodstream to body tissues and organs.
It is how a drug moves from intravascular space, e.g. blood vessels, to extravascular space, e.g. body tissues, as it is carried around the body by the circulatory system (figure 1)..

What is volume of distribution in pharmacokinetics SlideShare?

Volume of distribution (V) relates the amount of drug in the body to the concentration of drug (C) in blood or plasma: Drugs with very high volumes of distribution have much higher concentrations in extravascular tissue than in the vascular compartment, ie, they are not homogeneously distributed..

Where can drugs be distributed?

Each drug is uniquely distributed in the body.
Some drugs distribute mostly into fat, others remain in extracellular fluid, and others are bound extensively to specific tissues.
Many acidic drugs (eg, warfarin, aspirin) are highly protein-bound and thus have a small apparent volume of distribution..

Where does distribution occur in pharmacokinetics?

Distribution in pharmacology is a branch of pharmacokinetics which describes the reversible transfer of a drug from one location to another within the body.
Once a drug enters into systemic circulation by absorption or direct administration, it must be distributed into interstitial and intracellular fluids..