- 1.
Pharmacokinetics comprise a collection of equations that predict drug concentrations at the target site over time. 2.
Pharmacokinetic principles integrate drug absorption, distribution, metabolism, and excretion (ADME). How do pharmacokinetics principles work?
Pharmacokinetics uses mathematical equations (models) to describe the time course of ADME of xenobiotics in the body enabling us to better understand, interpret and even predict the nature and the extent of the biological effects (therapeutic or toxic) of xenobiotics..
What are the basic principles of clinical pharmacokinetics?
An understanding of 4 fundamental pharmacokinetic parameters will give the toxicologic pathologist a strong basis from which to appreciate how pharmacokinetics may be useful.
These parameters are clearance, volume of distribution, half-life, and bioavailability..
What are the basic principles of pharmacodynamics and pharmacokinetics?
Pharmacokinetics represents the absorption, distribution, metabolism, and elimination of drugs from the body.
Pharmacodynamics describes the interaction of drugs with target tissues..
What are the basic principles of pharmacokinetics?
Pharmacokinetics may be defined as what the body does to a drug.
It deals with the absorption, distribution, and elimination of drugs but also has utility in evaluating the time course of environmental (exogenous) toxicologic agents as well as endogenous compounds..
What are the fundamental principles of biopharmaceutics?
Biopharmaceutics examines the interrelationship of the physical/chemical properties of the drug, the dosage form (drug product) in which the drug is given, and the route of administration on the rate and extent of systemic drug absorption..
What are the general principles of pharmacology and pharmacokinetics?
A number of general pharmacokinetic principles and properties apply to all drugs; these include absorption, distribution, metabolism, elimination, half-life and steady-state concentration, and linear versus nonlinear pharmacokinetics..
What is pharmacokinetics and its principles?
Pharmacokinetics may be defined as what the body does to a drug.
It deals with the absorption, distribution, and elimination of drugs but also has utility in evaluating the time course of environmental (exogenous) toxicologic agents as well as endogenous compounds..
What is the principle of biopharmaceutics?
Biopharmaceutics examines the interrelationship of the physical/chemical properties of the drug, the dosage form (drug product) in which the drug is given, and the route of administration on the rate and extent of systemic drug absorption..
Why is it important to understand pharmacokinetics?
Clinical Significance
Pharmacokinetics, as a field, attempts to summarize the movement of drugs throughout the body and the actions of the body on the drug.
By using the above terms, theories, and equations, practitioners can better estimate the locations and concentrations of a drug in different areas of the body..
- Pharmacokinetics represents the absorption, distribution, metabolism, and elimination of drugs from the body.
Pharmacodynamics describes the interaction of drugs with target tissues. - There are four main components of pharmacokinetics: liberation, absorption, distribution, metabolism and excretion (LADME).
These are used to explain the various characteristics of different drugs in the body.
