Electrodes are placed at precise locations on the patient's head.
An electric current is sent through the electrodes into the brain, causing seizure activity that lasts under a minute.
Anesthesia ensures that the patient does not experience pain or feel the electrical pulses..
Background: Temporal interference (TI) stimulation is a novel technique that enables the non-invasive modulation of deep brain regions.
However, the implementation of this technology in humans has not been well-characterized or examined, including its safety and feasibility..
STr-applied TIS effectively reduces evoked-phasic DA release.
At intensity of ≥400μA, evoked phasic DA release is decreased by STr-applied TIS.
Cortex-applied TIS also reduces evoked phasic DA release..
Neural stimulation will occur at the targeted region, at the difference frequency, where the amplitude of the electric field envelope modulation is larger (Fig. 1a).
We call this strategy temporal interference (TI) stimulation since the interference of multiple electric fields enables its focality..
Background: Temporal interference (TI) stimulation is a new technique of non-invasive brain stimulation.
Envelope-modulated waveforms with two high-frequency carriers can activate neurons in target brain regions without stimulating the overlying cortex, which has been validated in mouse brains.Nov 29, 2021.
Temporal interference stimulation targets deep brain regions by modulating neural oscillations A finite element analysis of the effect of electrode area and inter-electrode distance on the spatial distribution of the current density in tDCS H.K.P.
Feirabend, H.
Choufoer, S.
Ploeger, J.
Holsheimer, J.D.
Van Gool .
And because TI stimulation has been proposed as a potential non-invasive alternative to deep brain stimulation (i.e. suprathreshold stimulation) ( Grossman et al., 2017 ), we modified a previously published compartmental model of a myelinated mammalian axon ( McIntyre et al., 2002) to assess the axonal response to TI stimulation.
Temporal interference (TI) is a non-invasive neurostimulation technique that utilizes high-frequency external electric fields to stimulate deep neuronal structures without affecting superficial, off-target structures.
TI represents a potential breakthrough for treating conditions, such as:
N.
Grossman, D.
Bono, N.
Dedic, S.B.
Kodandaramaiah, A.
Rudenko, H.J.
Suk, A.M.
Cassara, E.
Neufeld, N.
Kuster, L.-H.
Tsai, et al.
Noninvasive deep brain stimulation via temporally interfering electric fields Translating temporal interference brain stimulation to treat neurological and psychiatric conditions .
