A consortium of leading virologists, immunologists and physicians specialized in treating viral hepatitis, will use a newly designed therapeutic vaccine, TherVacB, as an immunotherapy to cure HBV.
TherVacB will be evaluated in a clinical trial starting in 2024 conducted in Europe and in Africa..
Tenofovir is a competitive inhibitor of HBV polymerase.
Tenofovir is a nucleotide analog, suggesting that it may inhibit viral replication by competing with natural nucleotides for binding to the active site of HBV polymerase..
Hepadnaviruses, including human hepatitis B virus (HBV), replicate through reverse transcription of an RNA intermediate, the pregenomic RNA (pgRNA)..
VIREAD is indicated for the treatment of chronic hepatitis B virus (HBV) in adults and pediatric patients 2 years of age and older weighing at least 10 kg.
Prior to or when initiating VIREAD, test patients for HBV infection and HIV-1 infection..
HBsAg (hepatitis B surface antigen) is the hallmark of HBV infection.
Anti‐HBc IgM (hepatitis B core antibody) is observed during acute infection.
Anti‐HBc (total antibody against HBV core antigen) indicates the presence of IgM and/or IgG against the core antigen..
Hepatitis B virus DNA polymerase is incorporated into the nucleocapsid along with the pre-genomic RNA (pgRNA).
Inside the capsid, the pgRNA undergoes reverse transcription, making the (-) DNA strand.
At the same time, most of the RNA template is degraded by the RNase activity of the polymerase..
Hepatitis B is a vaccine-preventable liver infection caused by the hepatitis B virus (HBV).
Hepatitis B is spread when blood, semen, or other body fluids from a person infected with the virus enters the body of someone who is not infected..
Elebsiran (VIR-2218) is under development for the treatment of hepatitis B and D virus infections.
It is administered through subcutaneous route and acts by targeting hepatitis B virus (HBV) genome including HBsAg.Sep 11, 2023.
The hepatitis B virus can be found in the blood, semen, and other body fluids of an infected person.
A person who has sex with an infected partner can become infected with the virus..
Epidemiology.
Africa is on the whole considered to have a high HBV endemicity.
HBV infection is hyperendemic [\x26gt; 8% of hepatitis B surface antigen (HBsAg) chronic carriers in the general population] only in some sub-Saharan countries such as Nigeria, Namibia, Gabon, Cameroon, Burkina Faso..
