Computational methods and tools in antimicrobial peptide research

  • How do you extract antimicrobial peptides?

    There are three main stages of plant AMP isolation: plant material homogenization, extraction, and saturation and purification of the extract.
    The extract obtained is usually fractionated by a series of liquid chromatography methods (Fig. 1)..

  • How do you make antimicrobial peptides?

    Microorganisms-Derived Antimicrobial Peptides
    Antimicrobial peptides can be obtained from microorganisms like bacteria and fungi, and some famous peptides are nisin, gramicidin from Lactococcus lactis, Bacillus subtilis, and Bacillus brevis (Cao et al., 2018)..

  • What is the database of anti microbial peptides?

    Database of Antimicrobial Activity and Structure of Peptides (DBAASP) is the manually-curated database.
    It has been developed to provide the scientific community with the information and analytical resources for designing antimicrobial compounds with a high therapeutic index..

  • What is the purpose of antimicrobial peptides?

    Antimicrobial peptides (AMPs) are multi-functional peptides whose fundamental biological role in vivo has been proposed to be the elimination of pathogenic microorganisms, including Gram-positive and -negative bacteria, fungi, and viruses..

  • Antimicrobial mechanism of antimicrobial peptides (AMPs).
    It includes the cell wall–targeting mechanism, membrane-targeting mechanism (only agglutination model is listed), translocation mechanism, and intracellular mechanism of intracellular activity.
  • Collection of antimicrobial peptides (CAMP), CAMPSign, and ClassAMP are open‐access resources that have been developed to enhance research on antimicrobial peptides (AMPs).
  • Microorganisms-Derived Antimicrobial Peptides
    Antimicrobial peptides can be obtained from microorganisms like bacteria and fungi, and some famous peptides are nisin, gramicidin from Lactococcus lactis, Bacillus subtilis, and Bacillus brevis (Cao et al., 2018).
Jun 24, 2021Recent studies demonstrate that they achieve their antimicrobial activity by disrupting various key cellular processes. Some peptides can even  IntroductionApproaches for Prediction of Approaches to Simulate AMP
Jun 24, 2021Some peptides can even use multiple mechanisms. Moreover, several intact proteins or protein fragments are now being shown to have inherent  IntroductionApproaches for Prediction of Approaches to Simulate AMP
Wet-lab investigations to find anti-microbial peptides are exceedingly costly, time-consuming, and even impossible for some species. Therefore, in order to choose the optimal AMPs candidate before to the in-vitro trials, an efficient computational method must be developed.

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