Micro-computed tomography as a platform for exploring drosophila development

  • What is the developmental process of Drosophila?

    Drosophila progress through 4 main stages of development: embryo, larva, pupa, and adult.
    The embryo is a fertilized egg that is about 0.5 mm long and oval shaped.
    Immediately after fertilization, the embryo undergoes rapid mitotic division without growth..

  • What is the Syncytium in Drosophila development?

    Drosophila Begins Its Development as a Syncytium
    Like the eggs of other insects, but unlike vertebrates, it begins its development in an unusual way: a series of nuclear divisions without cell division creates a syncytium.
    The early nuclear divisions are synchronous and extremely rapid, occurring about every 8 minutes..

  • Drosophila is ideal for genetic analyses, because it has only 4 chromosomes.
    This makes it easier to handle gene mutations, alone or even in combinations, i.e. to study their fundamental functions within genetic networks and decipher complex biological processes.
  • Morgan decided to use fruit flies to study how physical traits (for example, eye color) were transmitted from parents to offspring, and he was able to elegantly show that genes are stored in chromosomes and form the basis of heredity.
    This work won him a Nobel prize in 1933 and marked the birth of modern genetics.
  • This process is called complete metamorphosis.
    About 24 hours after fertilization, an egg hatches into a larva, which undergoes three molts taking about 5.5 to 6 days, after which it is called a pupa.
    The pupa metamorphoses into an adult fly, which takes about 3.5 to 4.5 days.
Summary: Micro-computed tomography in Drosophila is used to visualize all organs in an intact animal at micron resolution, providing a useful tool for whole-animal phenotyping.
Summary: Micro-computed tomography in Drosophila is used to visualize all organs in an intact animal at micron resolution, providing a useful tool for whole-animal phenotyping.

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