Isolde crystallography

  • How do you use Isolde in ChimeraX?

    Starting ISOLDE
    Assuming you already have ISOLDE installed (if not, you can do so via Tools/More Tools… in the ChimeraX menu), then you have three different ways to start it up: by typing isolde start in the command line; via the ChimeraX top menu: Tools/General/ISOLDE; or..

  • Obtaining ISOLDE

    1. Install and run ChimeraX
    2. Go to Tools/More Tools in the ChimeraX menu
    3. Find the ISOLDE link in the browser window that opens
    4. Click the big blue "Install" button on the right hand side, and wait for it to download/install
    5. ISOLDE should now appear in the menu under Tools/General/ISOLDE
What is ISOLDE? ISOLDE is a plugin to UCSF ChimeraX, designed to ease the task of macromolecular model building into low-to-medium resolution maps derived from crystallographic or electron cryo-microscopy (cryoEM) experiments.

Can Isolde generate maps from F/sigf data?

Additionally, ISOLDE will generate maps directly from crystallographic F/sigF data in MTZ format (and automatically re-calculate them when the model changes) and/or generate "static" maps from pre-calculated F/phi data

Any combination of these maps may be used simultaneously with the one model

What can it not do (yet)?

What is Isolde (interactive structure optimization by local direct exploration)?

Here, I introduce ISOLDE (Interactive Structure Optimization by Local Direct Exploration), an entirely rebuilt, extensible and scriptable interactive MDFF environment designed for intuitive and high-fidelity remodelling in low-resolution crystallographic or cryo-EM maps

What is Isolde?

ISOLDE is an immersive environment designed to ease the task of building high quality macromolecular models into low to medium resolution experimental maps, where the experimental information alone is insufficient to place individual atoms precisely

Historically this has been exceedingly challenging, for a number of reasons:


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