Crystallography based screening

  • Fragment Based Screening by Experimental Drug Development Centre (EDDC) Fragment Based Screening (FBS) is a validated approach towards finding high quality hits against challenging proteins that are classified as undruggable.
Crystallographic screening using high-concentration, aqueous, soaks with a library of ultra-low-molecular-weight compounds (MiniFrags). Identification of protein, ligand-binding, hot and warm spots to inform medicinal chemistry design strategy.

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