Jan 11, 2023LSIL (cyto)Large, mature cells (equal in size to a normal superficial or intermediate squamous cell) with abundant cytoplasmNuclear atypia.
Abstract. Introduction: Cellular changes of low-grade squamous intraepithelial lesion (LSIL) are uncommon in urine cytology. There is limited data regarding the clinical aspects and follow-up of patients with such findings. The aim of this study is to examine the clinicopathologic correlates of LSIL in urine cytology.
Low-grade squamous intraepithelial lesion (LSIL) is a common abnormal result on a Pap test. It's also known as mild dysplasia. LSIL means that your cervical cells show mild abnormalities. A LSIL, or abnormal Pap result, doesn't mean that you have cancer.
Do cytological changes in squamous cells indicate intraepithelial lesion?
Cytologic changes in squamous cells suggestive of a squamous intraepithelial lesion (increased N:C ratio and minimal nuclear changes) but qualitatively or quantitatively insufficient for a definitive interpretation .
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Do you need to treat LSIL?
According to a large 2017 study, most women with LSIL test positive for HPV.Tai YJ, et al. (2017).
Clinical management and risk reduction in women with low-grade squamous intraepithelial lesion cytology: A population-based cohort study.
DOI: 10.1371/journal.pone.0188203 Approximately 90 percent of them fight off an HPVinfection (replacing abnormal cells with healthy tissue) within 2 years.
This is especially true for teens and young women.
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Is LSIL a cancer?
LSIL is not cancer.
While a Pap test is used to screen for cervical cancer, it can’t determine for sure that abnormal cells are cancerous.
For that, you would need a cervical biopsy.
Pap tests can reveal precancerous cells and other abnormal changes that may lead to cervical cancer.
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Is LSIL contagious?
LSIL is not contagious, but HPV is a sexually transmitted infection (STI).
This means you can spread it through vaginal, anal, or oral sex.
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LSIL vs. high-grade squamous intraepithelial lesions (HSIL)
In about 10 percent of cases, LSIL progresses to high-grade squamous intraepithelial lesions (HSIL) within two years.Quint KD, et al. (2013).
Progression of cervical low grade squamous intraepithelial lesions: In search of prognostic biomarkers.
DOI: 10.1016/j.ejogrb.2013.07.012 This is more likely to occur in people who are 30 years old or older, compared to those in their 20s.
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Overview
Low-grade squamous intraepithelial lesion (LSIL) is a common abnormal result on a Pap test.
It’s also known as mild dysplasia.
LSIL means that your cervical cells show mild abnormalities.
A LSIL, or abnormal Pap result, doesn’t mean that you have cancer.
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What are the cytomorphologic features of LSIL?
One of the major cytomorphologic and an easily identifiable feature of LSIL is koilocytosis.
Koilocytes show raisinoid nuclei with sharply delineated perinuclear cytoplasmic clearing with irregular outline including:
- focal angulations [ Figure 4 ]
The nuclei show nuclear enlargement, hyperchromasia, and nuclear membrane irregularities.
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What are the symptoms of LSIL?
Cervical cancer screening recommendations
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What causes LSIL?
Most people with LSIL test positive for HPV.Tai YJ, et al. (2017).
Clinical management and risk reduction in women with low-grade squamous intraepithelial lesion cytology: A population-based cohort study.
DOI: 10.1371/journal.pone.0188203 Almost all cervical cancers are caused by HPV.How many cancers are linked with HPV each year? (2018).
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What does LSIL mean on a Pap test?
It’s also known as mild dysplasia.
LSIL means that your cervical cells show mild abnormalities.
A LSIL, or abnormal Pap result, doesn’t mean that you have cancer.
The tissue that covers your cervix is made up of squamous cells.
Pap tests are used to screen for cervical cancer, precancer, and other cervical cell abnormalities.
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What happens after LSIL is discovered?
If your Pap results show mild abnormalities (LSIL), your doctor will base their treatment recommendations on your age, how many abnormal Pap tests you’ve had, and other cervical cancer risk factors.
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What’s the link between LSIL and cancer?
LSIL is not cancer.
While a Pap test is used to screen for cervical cancer, it can’t determine for sure that abnormal cells are cancerous.
For that, you would need a cervical biopsy.
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What’s the recovery like?
LSIL (and HPV infections) often clear up on their own without treatment.
In these cases, no treatment or recovery is needed.
